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KMID : 1144820230290010026
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대한의생명과학회지
2023 Volume.29 No. 1 p.26 ~ p.33
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Ziziphus jujuba mill. Extract Promotes Myogenic Differentiation of C2C12 Skeletal Muscle Cells
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Park Gyeong-Do
Eun So-Young
Cheon Yoon-Hee
Chung Chong-Hyuk
Lee Chang-Hoon
Lee Myeung-Su
Kim Ju-Young
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Abstract
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Ziziphus jujuba Mill. (ZJM), a traditional folk medicine and functional food in South Korea and China, has been reported to having pharmacological activities against anti-cancer, anti-oxidative, and anti-obesity. However, the effect of ZJM related to myoblast differentiation has not been known. In this study, we investigated the effects and mechanism of ZJM on myogenic differentiation of C2C12 cells. ZJM promotes myogenic differentiation and elevates the formation of multinucleated myotube compared to the control group. ZJM significantly increased the mRNA and protein expression of MyHC1, myogenin and MyoD in dose- and time-dependent manner. Interestingly, ZJM significantly inhibited the mRNA and protein expression of protein degradation markers, atrogin-1 and MuRF-1, in dose- and time-dependent manner. Taken together, our data suggest that ZJM is a potential functional candidate for muscle growth and strength by promoting myogenic differentiation.
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KEYWORD
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Ziziphus jujuba mill., Myogenic differentiation, Muscle growth, Muscle strength, Muscle atrophy
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